Male Infertility and Glutathione

Are You Half The Man Your Father Was?

It is a well-known fact that sperm counts have dropped by half in the last 50 years, and that modern men have 20 percent less semen volume than their fathers (BMJ, 1992, volume 305).

A recent report from researchers in Aberdeen presented preliminary data that suggests the sperm concentration of the men seen in their clinic had declined by 29% over the past 14 years. (British Fertility Society; 5 January 2004)

Persistent organic pollutants (POPs) and endocrine-disrupting chemicals from normal, everyday plastics are known to cause reproductive damage, as documented in Theo Colborn's book "Our Stolen Future."

Damage to sperm caused by exposure to common chemicals like alcohol, pesticides in food, has been linked to lowered intelligence and behavioral disorders in children.

Lifestyle risk factors known to decrease sperm quality include

> Cigarette smoking

> Alcohol consumption

> Chronic stress

> Nutritional deficiencies.

Other reasons for infertility include congenital factors, and health conditions like prostatitis and diabetes that can affect sperm production.

Pollution is stealing our future, and there's little anyone can do to avoid it. There may not be a lot you can do to reduce your exposure to persistent environmental toxins.

But there are definite measures you can take to reduce the impact of the environmental pollutants and toxins on your body.

You can prevent and, to a certain extent, repair the damage they cause to your body, through a better lifestyle and nutrition.

Some nutritional therapies and antioxidants that have proven beneficial in treating male infertility and improving sperm counts, sperm morphology and motility include:

> Carnitine

> Arginine

> Zinc

> Selenium

> Vitamin B-12

> Vitamin C

> Vitamin E

> Glutathione

> Coenzyme Q10

Studies show that anti-oxidant supplementation - glutathione in particular - can improve sperm quality, and possibly increase your chances of conceiving.

If you smoke, drink, are exposed to stress, chemicals, radiation, pesticides or take medication or drugs (like sulfasalazine, ketoconazole, azulfidine, anabolic steroids, marijuana) that affect fertility, you should consider taking an antioxidant supplement to reverse some of the damage.

Why are Antioxidants Important for Sperm Quality?

Mammalian spermatozoa are coated by a membrane rich in polyunsaturated fatty acids. These fatty acids are extremely susceptible to oxidative damage by free radicals or Reactive Oxygen Species (ROS) by a process called lipid peroxidation (LPO).

Lipid peroxidation damages the sperm cell membrane. It is considered to be the key mechanism of ROS-induced sperm damage and leads to

> Loss of sperm motility

> Abnormal sperm morphology

> Reduced capacity for oocyte penetration

> Infertility

To protect sperm from damage, the body depends on powerful antioxidant enzymes in the body such as superoxide dismutase (SOD), catalase, and glutathione peroxidase/reductase (GPX/GRD).

Seminal plasma and spermatozoa have several antioxidant enzymes - glutathione peroxidase, glutathione reductase, superoxide dismutase.

Some amount of all the antioxidant enzymes, which may protect spermatozoa from oxidative attack, are also made by the epididymis during storage.

The glutathione peroxidase/reductase enzymes play a central role in the defense against oxidative damage in human sperm.

Why is Glutathione important for Sperm Quality and Fertility?

A decrease in levels of reduced glutathione (GSH) during sperm production is known to disrupt the membrane integrity of spermatozoa due to increased oxidative stress.

Intracellular glutathione levels of spermatozoa are known to be decreased in certain populations of infertile men. Compared with a control group, the infertile men in all groups had significantly higher levels of ROS and lower levels of total antioxidants.

There is strong clinical evidence to show that men diagnosed with infertility have high levels of oxidative stress that may impair the quality of their sperm.

In some groups, higher levels of ROS were associated with lower sperm counts and defective sperm structure, while lower antioxidant levels correlated with reduced sperm movement.

Previous evidence has also shown that oxidative stress can decrease a sperm's life span, its motility, and its ability to penetrate the oocyst, or egg cell.

Up to 40% of men with unexplained male infertility have higher levels of free radical activity in their bodies.

Because men with high levels of ROS have a seven-fold lower likelihood of inducing a pregnancy than men with lower levels, researchers recommend that treatment for infertile men should include strategies to reduce oxidative stress and improve sperm quality.

How can Glutathione help in the Treatment of Infertility?

Glutathione is not only vital to sperm antioxidant defenses, but selenium and glutathione are essential to the formation of "phospholipid hydroperoxide glutathione peroxidase" - an enzyme present in spermatids - which becomes a structural protein in the mid-piece of mature spermatozoa.

When either substance is deficient, it can lead to instability of the mid-piece of the spermatozoa, resulting in defective motility.

Free radical scavengers - such as glutathione - that restore the structure and function of poly-unsaturated fatty acids (PUFA) in the cell membrane, can be used to treat these cases.

In a double-blind cross-over study of twenty infertile men, treatment with glutathione led to a statistically significant improvement of the sperm quality.

The study concerned men in whom the sperm quality was poor due to unilateral varicocele or germ-free genital tract inflammation - two conditions in which ROS or other toxic compounds are indicated as causative factors.

Treatment with glutathione was also found to have a statistically significantly positive effect on sperm motility (in particular forward motility) and on sperm morphology.

The findings of these studies indicate that glutathione therapy could represent a possible therapeutical tool in cases where ROS or exposure to toxins is the probable cause of infertility.

Read the complete report with references on Male Infertility and Glutathione

Copyright © 2004 Priya Shah

From Cell to Super Cell - with Glutathione

Imagine you're a cell.

Inside your body runs the machinery that creates life itself. But as that machinery keeps running, day after day, you begin to get worn out - the friction and the processes that cause damage (here the "free-radicals" - highly destructive little entities generated by biochemical processes, as well as pollutants, UV radiation and other sources) start to create havoc and you begin to lose the battle to disease, old age and ultimately death.

In fact your battle would be over much sooner were it not for the numerous mechanisms that you and other mammalian cells evolved over millions of years, as protection from the injury that can result from your normal functional processes. The foremost among these internal protective systems is the "Glutathione antioxidant system."

Glutathione, a small molecule composed of three amino acids - glycine, glutamate and cysteine - acts as your cellular Super-Mop, soaking up "free-radicals" (with the help of the sulfur-containing portion of the cysteine molecule), protecting your cellular membranes and internal organs from the cascading destruction they can cause.

Besides being the major antioxidant that you produce as protection from "free-radicals," glutathione is also a very important detoxifying agent, enabling you to get rid of undesirable toxins and pollutants. If you were a liver, kidney or lung cell, you would contain high levels of glutathione, as you'd be exposed to the greatest levels of toxins.

Glutathione also helps you dispose of many cancer- producing chemicals, heavy metals, drug metabolites etc. that invade the pristine recesses of your cellular world. And Mother Nature (the first recycler) also designed you to use glutathione to recycle other well-known antioxidants such as vitamin C and vitamin E, keeping them in their active state.

If you were a cell delegated to the immune system department, you would require glutathione for many of the intricate steps needed to carry out your essential immune response functions - such as multiplying to make many clones of yourself, to mount a full-bodied immune response, or "neutralizing" undesirable elements of the cellular community, like cancerous or virally infected cells.

But your finicky cell membrane does not allow whole glutathione molecules to cross over directly into your cellular spaces. And every time a molecule of glutathione neutralizes a destructive free-radical or toxin, it fatally binds with the undesirable element and is washed out with them in the bile or the urine.

So how do you replenish your stores and get your daily fix of glutathione? Simple. You manufacture it in your cellular factory, from its raw materials - glycine, glutamate and cysteine.

If your human eats a diet high in fresh fruits and vegetables and freshly prepared meats, you should get be getting enough glutamate and glycine. But cystine comes mostly from eggs, milk and cheese. And when eggs, milk and cheese are cooked or processed, the composition of Cystine is changed to Cysteine (small difference in spelling, but BIG difference in action). While still a valuable protein, it can no longer feed your glutathione levels.

If you can get a sufficient supply of cysteine (which determines the rate at which you can make glutathione), your arsenal is well- stocked. If not, you and your human are at a strategic disadvantage in the battle of "Cell v/s Free-radical Destroyers."

As a normal, healthy cell, increasing your glutathione levels could help you and your human maintain that strategic advantage in the battle against free-radicals. If you're not really in your prime, boosting your levels could tip the scales in your favor, and help you fight the cellular damage that causes disease and aging.

Copyright 2002 Priya Shah

What Would You Do For a Klondike Bar?

Unfortunately, the words "diet" and "cheating" go hand in hand. When you say, "I'm on a DIET", it usually means you are depriving yourself of something. Diets do not work; they are restrictive and can become exceedingly frustrating, leading you to "cheat". The more you restrict calories and the tempting treats you love, the more likely you are to binge eat. This is counterproductive in a fat loss program and will prevent you from becoming lean.

I'm sure you know the scenario; you embark on a weight loss plan (a.k.a. A Very Low Calorie Diet) fully confident and filled with motivation and willpower. You go out to eat and turn down the dessert you desperately want and then have to sit at the table and watch EVERYONE else gobble down their brownie ala- mode or a slice of Death by Chocolate cake. As the days of deprivation go on you suddenly find yourself thinking about food more and more. You dream about the pint of ice cream that's calling your name. You begin to bargain with yourself, promising to do extra cardio or to fast in exchange for a cheat day.

This, of course, never comes to pass and you find yourself "starting over" on your DIET once a week. Worse yet, you have made no progress and have slowed your metabolism to a grinding halt by eat too few calories. The best way to lose weight is to adopt a balanced meal plan you can stick to for life! This means you can still enjoy the so-called "forbidden foods" you love, only less often and in moderation. If you consistently eat "clean" and "balanced" your desire for the "bad stuff" will eventually disappear.

If you have SEVERE difficulty resisting sugar and constantly have a high sugar craving, this may indicate that your diet is substantially low in "beneficial" fat and it is likely that you have an intestinal flora imbalance. Beneficial fats regulate mood, taste and fulfillment hormones that help you feel satisfied and reduce cravings. An intestinal flora imbalance means certain "shut off" nutrients that reduce the need for sugars are not fully synthesized into your blood stream. Combined, both of these problems cause you to hold onto fat and create cravings for simple sugars.

The solution is to incorporate beneficial fats. Try drizzling 1 to 2 tbsp. of raw safflower, canola, olive or flax oil on your high fiber based vegetables and proteins. Either sauté, grill or make a soup with vegetables like zucchini, yellow squash, green beans, spinach and mushrooms to name a few. Use any of the oils previously mentioned except flax oil. Flax oil is NOT for cooking.

Chewing your proteins more fully may combat the intestinal flora imbalance. Instead of trying to digest large pieces, chew more fully to give your protein sources greater surface area. Your protein sources for optimum fat loss are eggs, egg whites, white fish (like cod, halibut, and orange roughy), chicken or turkey breast.

Whatever you do, DON'T give up! DO whatever it takes to "clean up" your eating plan and banish your food demons.

My fat loss and fitness plan "Every Body Loses" will give you the tools you need to begin a healthy weight loss program. The style of eating and exercising outlined in my book is one that you can follow for life without feeling deprived.

Be Well & Stay Fit

Aimee Deak

Personal Trainer & Nutrition Analyst

What Would You Do For a Klondike Bar?

Unfortunately, the words "diet" and "cheating" go hand in hand. When you say, "I'm on a DIET", it usually means you are depriving yourself of something. Diets do not work; they are restrictive and can become exceedingly frustrating, leading you to "cheat". The more you restrict calories and the tempting treats you love, the more likely you are to binge eat. This is counterproductive in a fat loss program and will prevent you from becoming lean.

I'm sure you know the scenario; you embark on a weight loss plan (a.k.a. A Very Low Calorie Diet) fully confident and filled with motivation and willpower. You go out to eat and turn down the dessert you desperately want and then have to sit at the table and watch EVERYONE else gobble down their brownie ala- mode or a slice of Death by Chocolate cake. As the days of deprivation go on you suddenly find yourself thinking about food more and more. You dream about the pint of ice cream that's calling your name. You begin to bargain with yourself, promising to do extra cardio or to fast in exchange for a cheat day.

This, of course, never comes to pass and you find yourself "starting over" on your DIET once a week. Worse yet, you have made no progress and have slowed your metabolism to a grinding halt by eat too few calories. The best way to lose weight is to adopt a balanced meal plan you can stick to for life! This means you can still enjoy the so-called "forbidden foods" you love, only less often and in moderation. If you consistently eat "clean" and "balanced" your desire for the "bad stuff" will eventually disappear.

If you have SEVERE difficulty resisting sugar and constantly have a high sugar craving, this may indicate that your diet is substantially low in "beneficial" fat and it is likely that you have an intestinal flora imbalance. Beneficial fats regulate mood, taste and fulfillment hormones that help you feel satisfied and reduce cravings. An intestinal flora imbalance means certain "shut off" nutrients that reduce the need for sugars are not fully synthesized into your blood stream. Combined, both of these problems cause you to hold onto fat and create cravings for simple sugars.

The solution is to incorporate beneficial fats. Try drizzling 1 to 2 tbsp. of raw safflower, canola, olive or flax oil on your high fiber based vegetables and proteins. Either sauté, grill or make a soup with vegetables like zucchini, yellow squash, green beans, spinach and mushrooms to name a few. Use any of the oils previously mentioned except flax oil. Flax oil is NOT for cooking.

Chewing your proteins more fully may combat the intestinal flora imbalance. Instead of trying to digest large pieces, chew more fully to give your protein sources greater surface area. Your protein sources for optimum fat loss are eggs, egg whites, white fish (like cod, halibut, and orange roughy), chicken or turkey breast.

Whatever you do, DON'T give up! DO whatever it takes to "clean up" your eating plan and banish your food demons.

My fat loss and fitness plan "Every Body Loses" will give you the tools you need to begin a healthy weight loss program. The style of eating and exercising outlined in my book is one that you can follow for life without feeling deprived.

Be Well & Stay Fit

Aimee Deak

Personal Trainer & Nutrition Analyst

Male Infertility and Glutathione

Are You Half The Man Your Father Was?

It is a well-known fact that sperm counts have dropped by half in the last 50 years, and that modern men have 20 percent less semen volume than their fathers (BMJ, 1992, volume 305).

A recent report from researchers in Aberdeen presented preliminary data that suggests the sperm concentration of the men seen in their clinic had declined by 29% over the past 14 years. (British Fertility Society; 5 January 2004)

Persistent organic pollutants (POPs) and endocrine-disrupting chemicals from normal, everyday plastics are known to cause reproductive damage, as documented in Theo Colborn's book "Our Stolen Future."

Damage to sperm caused by exposure to common chemicals like alcohol, pesticides in food, has been linked to lowered intelligence and behavioral disorders in children.

Lifestyle risk factors known to decrease sperm quality include

> Cigarette smoking

> Alcohol consumption

> Chronic stress

> Nutritional deficiencies.

Other reasons for infertility include congenital factors, and health conditions like prostatitis and diabetes that can affect sperm production.

Pollution is stealing our future, and there's little anyone can do to avoid it. There may not be a lot you can do to reduce your exposure to persistent environmental toxins.

But there are definite measures you can take to reduce the impact of the environmental pollutants and toxins on your body.

You can prevent and, to a certain extent, repair the damage they cause to your body, through a better lifestyle and nutrition.

Some nutritional therapies and antioxidants that have proven beneficial in treating male infertility and improving sperm counts, sperm morphology and motility include:

> Carnitine

> Arginine

> Zinc

> Selenium

> Vitamin B-12

> Vitamin C

> Vitamin E

> Glutathione

> Coenzyme Q10

Studies show that anti-oxidant supplementation - glutathione in particular - can improve sperm quality, and possibly increase your chances of conceiving.

If you smoke, drink, are exposed to stress, chemicals, radiation, pesticides or take medication or drugs (like sulfasalazine, ketoconazole, azulfidine, anabolic steroids, marijuana) that affect fertility, you should consider taking an antioxidant supplement to reverse some of the damage.

Why are Antioxidants Important for Sperm Quality?

Mammalian spermatozoa are coated by a membrane rich in polyunsaturated fatty acids. These fatty acids are extremely susceptible to oxidative damage by free radicals or Reactive Oxygen Species (ROS) by a process called lipid peroxidation (LPO).

Lipid peroxidation damages the sperm cell membrane. It is considered to be the key mechanism of ROS-induced sperm damage and leads to

> Loss of sperm motility

> Abnormal sperm morphology

> Reduced capacity for oocyte penetration

> Infertility

To protect sperm from damage, the body depends on powerful antioxidant enzymes in the body such as superoxide dismutase (SOD), catalase, and glutathione peroxidase/reductase (GPX/GRD).

Seminal plasma and spermatozoa have several antioxidant enzymes - glutathione peroxidase, glutathione reductase, superoxide dismutase.

Some amount of all the antioxidant enzymes, which may protect spermatozoa from oxidative attack, are also made by the epididymis during storage.

The glutathione peroxidase/reductase enzymes play a central role in the defense against oxidative damage in human sperm.

Why is Glutathione important for Sperm Quality and Fertility?

A decrease in levels of reduced glutathione (GSH) during sperm production is known to disrupt the membrane integrity of spermatozoa due to increased oxidative stress.

Intracellular glutathione levels of spermatozoa are known to be decreased in certain populations of infertile men. Compared with a control group, the infertile men in all groups had significantly higher levels of ROS and lower levels of total antioxidants.

There is strong clinical evidence to show that men diagnosed with infertility have high levels of oxidative stress that may impair the quality of their sperm.

In some groups, higher levels of ROS were associated with lower sperm counts and defective sperm structure, while lower antioxidant levels correlated with reduced sperm movement.

Previous evidence has also shown that oxidative stress can decrease a sperm's life span, its motility, and its ability to penetrate the oocyst, or egg cell.

Up to 40% of men with unexplained male infertility have higher levels of free radical activity in their bodies.

Because men with high levels of ROS have a seven-fold lower likelihood of inducing a pregnancy than men with lower levels, researchers recommend that treatment for infertile men should include strategies to reduce oxidative stress and improve sperm quality.

How can Glutathione help in the Treatment of Infertility?

Glutathione is not only vital to sperm antioxidant defenses, but selenium and glutathione are essential to the formation of "phospholipid hydroperoxide glutathione peroxidase" - an enzyme present in spermatids - which becomes a structural protein in the mid-piece of mature spermatozoa.

When either substance is deficient, it can lead to instability of the mid-piece of the spermatozoa, resulting in defective motility.

Free radical scavengers - such as glutathione - that restore the structure and function of poly-unsaturated fatty acids (PUFA) in the cell membrane, can be used to treat these cases.

In a double-blind cross-over study of twenty infertile men, treatment with glutathione led to a statistically significant improvement of the sperm quality.

The study concerned men in whom the sperm quality was poor due to unilateral varicocele or germ-free genital tract inflammation - two conditions in which ROS or other toxic compounds are indicated as causative factors.

Treatment with glutathione was also found to have a statistically significantly positive effect on sperm motility (in particular forward motility) and on sperm morphology.

The findings of these studies indicate that glutathione therapy could represent a possible therapeutical tool in cases where ROS or exposure to toxins is the probable cause of infertility.

Read the complete report with references on Male Infertility and Glutathione

Copyright © 2004 Priya Shah

Male Infertility and Glutathione

Are You Half The Man Your Father Was?

It is a well-known fact that sperm counts have dropped by half in the last 50 years, and that modern men have 20 percent less semen volume than their fathers (BMJ, 1992, volume 305).

A recent report from researchers in Aberdeen presented preliminary data that suggests the sperm concentration of the men seen in their clinic had declined by 29% over the past 14 years. (British Fertility Society; 5 January 2004)

Persistent organic pollutants (POPs) and endocrine-disrupting chemicals from normal, everyday plastics are known to cause reproductive damage, as documented in Theo Colborn's book "Our Stolen Future."

Damage to sperm caused by exposure to common chemicals like alcohol, pesticides in food, has been linked to lowered intelligence and behavioral disorders in children.

Lifestyle risk factors known to decrease sperm quality include

> Cigarette smoking

> Alcohol consumption

> Chronic stress

> Nutritional deficiencies.

Other reasons for infertility include congenital factors, and health conditions like prostatitis and diabetes that can affect sperm production.

Pollution is stealing our future, and there's little anyone can do to avoid it. There may not be a lot you can do to reduce your exposure to persistent environmental toxins.

But there are definite measures you can take to reduce the impact of the environmental pollutants and toxins on your body.

You can prevent and, to a certain extent, repair the damage they cause to your body, through a better lifestyle and nutrition.

Some nutritional therapies and antioxidants that have proven beneficial in treating male infertility and improving sperm counts, sperm morphology and motility include:

> Carnitine

> Arginine

> Zinc

> Selenium

> Vitamin B-12

> Vitamin C

> Vitamin E

> Glutathione

> Coenzyme Q10

Studies show that anti-oxidant supplementation - glutathione in particular - can improve sperm quality, and possibly increase your chances of conceiving.

If you smoke, drink, are exposed to stress, chemicals, radiation, pesticides or take medication or drugs (like sulfasalazine, ketoconazole, azulfidine, anabolic steroids, marijuana) that affect fertility, you should consider taking an antioxidant supplement to reverse some of the damage.

Why are Antioxidants Important for Sperm Quality?

Mammalian spermatozoa are coated by a membrane rich in polyunsaturated fatty acids. These fatty acids are extremely susceptible to oxidative damage by free radicals or Reactive Oxygen Species (ROS) by a process called lipid peroxidation (LPO).

Lipid peroxidation damages the sperm cell membrane. It is considered to be the key mechanism of ROS-induced sperm damage and leads to

> Loss of sperm motility

> Abnormal sperm morphology

> Reduced capacity for oocyte penetration

> Infertility

To protect sperm from damage, the body depends on powerful antioxidant enzymes in the body such as superoxide dismutase (SOD), catalase, and glutathione peroxidase/reductase (GPX/GRD).

Seminal plasma and spermatozoa have several antioxidant enzymes - glutathione peroxidase, glutathione reductase, superoxide dismutase.

Some amount of all the antioxidant enzymes, which may protect spermatozoa from oxidative attack, are also made by the epididymis during storage.

The glutathione peroxidase/reductase enzymes play a central role in the defense against oxidative damage in human sperm.

Why is Glutathione important for Sperm Quality and Fertility?

A decrease in levels of reduced glutathione (GSH) during sperm production is known to disrupt the membrane integrity of spermatozoa due to increased oxidative stress.

Intracellular glutathione levels of spermatozoa are known to be decreased in certain populations of infertile men. Compared with a control group, the infertile men in all groups had significantly higher levels of ROS and lower levels of total antioxidants.

There is strong clinical evidence to show that men diagnosed with infertility have high levels of oxidative stress that may impair the quality of their sperm.

In some groups, higher levels of ROS were associated with lower sperm counts and defective sperm structure, while lower antioxidant levels correlated with reduced sperm movement.

Previous evidence has also shown that oxidative stress can decrease a sperm's life span, its motility, and its ability to penetrate the oocyst, or egg cell.

Up to 40% of men with unexplained male infertility have higher levels of free radical activity in their bodies.

Because men with high levels of ROS have a seven-fold lower likelihood of inducing a pregnancy than men with lower levels, researchers recommend that treatment for infertile men should include strategies to reduce oxidative stress and improve sperm quality.

How can Glutathione help in the Treatment of Infertility?

Glutathione is not only vital to sperm antioxidant defenses, but selenium and glutathione are essential to the formation of "phospholipid hydroperoxide glutathione peroxidase" - an enzyme present in spermatids - which becomes a structural protein in the mid-piece of mature spermatozoa.

When either substance is deficient, it can lead to instability of the mid-piece of the spermatozoa, resulting in defective motility.

Free radical scavengers - such as glutathione - that restore the structure and function of poly-unsaturated fatty acids (PUFA) in the cell membrane, can be used to treat these cases.

In a double-blind cross-over study of twenty infertile men, treatment with glutathione led to a statistically significant improvement of the sperm quality.

The study concerned men in whom the sperm quality was poor due to unilateral varicocele or germ-free genital tract inflammation - two conditions in which ROS or other toxic compounds are indicated as causative factors.

Treatment with glutathione was also found to have a statistically significantly positive effect on sperm motility (in particular forward motility) and on sperm morphology.

The findings of these studies indicate that glutathione therapy could represent a possible therapeutical tool in cases where ROS or exposure to toxins is the probable cause of infertility.

Read the complete report with references on Male Infertility and Glutathione

Copyright © 2004 Priya Shah